Enhanced uptake of blood coagulation factorVIIIcontaining immune complexes by antigen presenting cells

Individual cathepsins degrade immune complexes internalized by antigen-presenting cells via Fcgamma receptors.

We have analyzed the intracellular degradation of an immune complex after its FcgammaR-mediated uptake in antigen-presenting cells (APC). Mice that lack the cathepsins (Cat) S, L, B and D allowed us to assess the direct contribution of these individual proteases to the processing events observed. CatS and CatB mediate the bulk of degradation of the Ig-125I-labeled F(ab')2 immune complex deliver...

Immune regulation by antigen-presenting cell EVs

Introduction Extracellular vesicles (EVs) are comprised of both microvesicles, released from the plasma membrane by shedding, and nanovesicles or exosomes, generated by reverse budding of multivesicular bodies. These different types of vesicles are characterized predominantly by their size, with exosomes ranging from 30 to 100 nm and microvesicles usually being larger than 200 nm (1–4). Althoug...

Antigen-Antibody Immune Complexes

Role of antigen-presenting cells in innate immune system.

Activation of antigen-presenting cells (APC) and natural killer (NK) cells initiates the production of various proinflammatory cytokines including interleukin 12 (IL-12), interferon gamma (IFN-gamma) and nitric oxide (NO), which are important in the innate immune response for controlling infection by intracellular pathogens. In this review, we focus on these cytokines produced by APC and summar...

Immune Reactions and Blood Coagulation

The prominence of thrombosis in the pathogenesis of the Arthns phenomenon (1, 2), the alterations in the clotting mechanism seen in experimental anaphylaxis (3), and the occurrence of "fibrinoid" in lesions generally considered to be due to hypersensit ivity suggest tha t the interaction of antigen and antibody in vivo may in some manner init iate coagulation. Experiments to be reported here in...